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Mutations in one cell type set off cancer in another

By Anette Breindl
Science Editor

Wednesday, January 15, 2014
It’s an old story: Mutations lead to cancer. Except that in this case, mutations in one cell type lead to cancer in another. That’s the upshot of work reported in the Jan. 15, 2014, advance online issue of Nature, by scientists from Columbia University. In their studies, the researchers found that an activating mutation in beta-catenin in osteoblasts, bone-forming cells of the bone marrow niche, ultimately led to acute myeloid leukemia (AML), which is caused by the proliferation of blood-forming, or hematopoietic, stem cells.

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