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The Meek Shall Inherit the Pharmacy

New Concept of Hub Signaling May Lead to Specific Targeting

By Anette Breindl
Science Editor

Monday, October 14, 2013
In some ways, the best targets for therapeutic intervention are the worst ones, too – because they are all things to all people. “Many of the key regulators of cell function are signaling hubs,” Alexander Hoffmann told BioWorld Today. And because they are signaling hubs, targeting them pharmacologically is a risky business. NFkB is a prime example. A transcription factor that regulates inflammation when it is activated in response to cytokines and chemokines, NFkB’s levels are elevated in many cancers, and it also plays a role in autoimmune disease.

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