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New 'Paradigm' in heart failure; Novartis' combo pill to have 'major impact'

By Nuala Moran
Staff Writer

Tuesday, September 2, 2014
LONDON – Novartis AG hailed the results of its Paradigm trial of LCZ696 as "a historical moment in the treatment of heart failure," with the combined ACE/neprilysin inhibitor reducing deaths by 20 percent, cutting hospitalizations by 21 percent and offering better quality of life, compared to treatment with ACE inhibitor enalapril alone.

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