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Neuroimmunology Strikes Again

Newly Found Interaction Plays Role in Alzheimer’s

By Anette Breindl
Science Editor

Friday, September 20, 2013
In work that sheds light on both the toxicity of amyloid beta and the role that immune system molecules play in the brain, researchers have shown that amyloid beta oligomers can weaken synapses by binding to the PirB receptor. In animal models of Alzheimer’s disease, such weakening went along with cognitive problems. And long before any memory problems developed in such animals, the interaction of amyloid-beta oligomers and the PirB receptor also reduced plasticity in the developing brain.

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