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Novel mitochondrial control pathway plays a role in aging

By Anette Breindl
Science Editor

Thursday, December 26, 2013
Researchers have gained new insights into the communication between mitochondria and the rest of cell, and how such communication goes awry during aging. Their results suggest new ways to prevent or reverse age-related diseases. “We have identified an entire pathway that regulates mitochondrial function, and is dysregulated during aging,” first author Ana Gomes told BioWorld Today. The team published their findings in the Dec. 19, 2013, issue of Cell. Mitochondrial function is known to be regulated by PPAR-gamma and its coactivator PGC-1, a pathway that is successfully targeted by several diabetes drugs.

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