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Friday, November 30, 2012
• Epizyme Inc., of Cambridge, Mass., said preclinical data showed that treatment with EPZ-5676, an S-adenosyl methionine competitive DOT1L inhibitor, showed dose-dependent antitumor activity in a genetically defined rat model of MLL-rearranged leukemia, when given as a continuous infusion for 21 days, and resulted in complete tumor regression with the highest dose tested.

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