• Provectus Pharmaceuticals Inc., of Knoxville, Tenn., said researchers at the Moffitt Cancer Center showed that a single dose of PV-10 in mice with melanoma produced a significant reduction in the skin cancer lesions, as well as a sizeable reduction in melanoma tumors that had spread to the lungs. PV-10 is a solution developed from Rose Bengal, a water-soluble dye commonly used to stain damaged cells in the eye.