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Parkinson’s kinase harms via presence, not activity
By Anette Breindl
Tuesday, January 7, 2014
A kinase that is often mutated in Parkinson’s disease, the leucine-rich repeat kinase (LRRK2), leads to trouble not because of its kinase activity, but because it interacts with another culprit in Parkinson’s: the protein alpha-synuclein. Researchers from the Gladstone Institutes published those findings in the Jan. 8, 2014, issue of the Journal of Neuroscience. The clinical symptoms of Parkinson’s disease, a neurodegenerative disorder that leads to motor as well as cognitive problems, are due to the death of neurons in the substantia nigra.
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