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Stick a Replication Fork in It

PARP Inhibitors Target Cohesin-Mutated Cells

By Anette Breindl
Science Editor

Monday, March 19, 2012
Researchers from the University of British Columbia have identified a new set of mutations that make tumor cells vulnerable to Poly(ADP-ribose) polymerase, or PARP, inhibitors. The genes in question, for cohesins, join BRCA and RAD51D as possible biomarkers for tumors that are sensitive to PARP inhibitors.

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