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Partial reprogramming slows expedited and regular aging

By Anette Breindl
Senior Science Editor

Monday, December 19, 2016

The Yamanaka factors, which are used to create induced pluripotent stem cells (iPSCs) in test tubes, could slow down premature aging of mice with progeria, as well as certain aspects of regular aging, when they were transiently expressed in mice. By keeping expression times short and intermittent, the scientists prevented cells from becoming fully stem cell-like, thus avoiding the formation of tumors in the animals.

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