Pharma: Clinic Roundup

• Shire plc, of Dublin, Ireland, said that once-daily SPD476 (MMX mesalamine) did not reduce the rate of recurrence of diverticulitis over a 2-year treatment period in a Phase III (PREVENT2) trial. It also failed to separate from placebo on its secondary endpoint. A second trial (PREVENT1) still has results pending, but the company does not intend to pursue a regulatory filing for MMX mesalamine in that indication.