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Crystal Clear

Picture-Perfect Study of HIV’s Co-receptor

By Anette Breindl
Science Editor

Monday, September 16, 2013
Researchers have deciphered the crystal structure of the HIV co-receptor bound to an indirect inhibitor of viral entry, Celsentri/Selzentry (maraviroc, ViiV Healthcare Co.). The findings could offer valuable clues for how to design the next generation of such inhibitors. HIV uses two receptors to enter the helper T cells it infects, corresponding author Beili Wu of the Shanghai Academy of Materia Medica told reporters at a press conference announcing the findings. Its main receptor is the CD4 receptor. But in addition, it needs to attach to one of two co-receptors – either CXCR4 or CCR5.

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