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Better than Antibodies?

Plumbing RNAi's Potential: Medicines Co., Alnylam Join Up

By Randy Osborne
Staff Writer

Monday, February 4, 2013
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The Medicines Co. likes Alnylam Pharmaceuticals Inc.'s RNA interference (RNAi) approach to blocking proprotein convertase subtilisin/kexin type 9 (PCSK9) enough to pay $25 million up front plus as much as $180 million in milestone payments, but how the method might stand up against late-stage antibodies remains to be seen clinically.

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