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REAL PROTEINS FROM PSEUDOGENES

Researchers publish draft proteome maps

By Anette Breindl
Science Editor

Wednesday, May 28, 2014
Two separate draft catalogs of the human proteome have brought new insights into the relationship between genes and proteins, identifying both proteins that were transcribed from supposedly noncoding regions of the genome, and genes that never got turned into proteins even though they had all the bells and whistles that flag them as bona fide protein-coding genes. Scientifically, "It's telling us that we really don't know the rules of our own genome so well," Johns Hopkins University's Akhilesh Pandey told BioWorld Today. Pandey is the senior author of one of the two papers, which appeared back to back in the May 29, 2014, issue of Nature. Proteins are technically more challenging to study than genes. They are also more diverse.

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