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Ripe for exploration: the mouse with human antibodies

By Sharon Kingman
Staff Writer

Monday, March 17, 2014
LONDON – The advent of mice that produce the full range of human antibodies is set to trigger an explosion in new therapies for human diseases and to revolutionize vaccine research. Derived from embryonic stem cells into which all the genes encoding the entire human antibody repertoire have been inserted, the mice are fertile and apparently normal in every other way. The antibodies the animals produce have all the properties desired for therapeutic antibodies, studies suggest. The breakthrough ends years, if not decades, of attempts aimed at finding a way to produce fully humanized antibodies for therapeutic use.

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