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There's An APP (Mutation) for That

Same Variant Protects Against Alzheimer's, Cognitive Decline

By Anette Breindl
Science Editor

Thursday, July 12, 2012
Researchers have identified a gene variant that is protective against both late-onset Alzheimer's disease and age-related cognitive decline. Beyond its scientific novelty, the work provides a proof of concept that inhibiting beta-secretase, or BACE1, can be effective against both Alzheimer's disease and age-related cognitive decline – because that is the net effect of the variant that senior author Kari Stefansson and his team have identified.

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