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Leaky Blood-Brain Barrier to Blame

Scientists Show Why ApoE4 is Alzheimer's Disease Risk Factor

By Anette Breindl
Science Editor

Monday, May 21, 2012
Having the ApoE4 gene variant is one of the strongest risk factors for developing late-onset Alzheimer's disease. Now, scientists have found out why. ApoE4 is less able to control production of the inflammatory cytokine cyclophilin A than other variants of the ApoE gene, and high levels of cyclophilin A set off inflammatory processes that ultimately damage the blood-brain barrier and the brain vasculature.

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