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Screening Study Delivers a New Target For Cystic Fibrosis

By Sharon Kingman
Staff Writer

Tuesday, September 17, 2013
LONDON – The prospects for new drugs to treat cystic fibrosis have improved, following a project to screen thousands of genes to determine which of their protein products affects the function of a molecular sodium channel found on cell membranes. Researchers based in Portugal and Germany inhibited roughly 7,000 genes in turn to find out which ones regulated the function of the epithelial sodium channel (ENaC). Among the more than 700 genes that turned out to enhance the function of ENaC was one known as DGKi, which encodes a kinase, and another called CNTFR.

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