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Selective ribosome shutdown offers new targeting possibilities

By Anette Breindl
Senior Science Editor

Wednesday, March 29, 2017

The small molecule PF-06446846 selectively blocked the translation of PCSK9 messenger RNA, showing that the ribosome can be targeted in a protein-specific manner. Researchers from the University of California Berkeley and Pfizer Inc. reported the findings in the March 21, 2017, online issue of PLoS Biology.

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