DUBLIN – Takeda Pharmaceutical Co. Ltd. edged closer to a deal to acquire Shire plc, with a revised cash-and-shares offer that values the Dublin-based firm at £49 per share or about £46 billion (US$64.2 billion). The offer comprises £21.75 in cash plus £27.26 in Takeda stock, the equivalent of about £20.4 billion in cash plus £25.6 billion in Takeda stock. If they accept the offer, Shire shareholders would hold about 50 percent of the enlarged company's equity, in addition to getting the up-front cash.