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WHEN ANTIBODIES ATTACK

Small firms targeting therapies at the complement system

By Brian Orelli
Contributing Writer

Monday, April 21, 2014

The complement system is designed to kill pathogens through a signal cascade that results in cell lysis, removal of the pathogens through phagocytosis, and alerting other immune system cells to help with infections. Signals come from three different pathways – classical, lectin and alternative – culminating at the C3 protein of the cascade.

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