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In some cases, more to Alzheimer’s than just amyloids

By Anette Breindl
Science Editor

Thursday, April 3, 2014
Researchers have identified a biochemical pathway that destabilizes spines in knock-in mice bearing a protein linked to some cases of familial Alzheimer’s disease (AD). The work suggests a novel therapeutic approach to AD and age-related memory loss that is independent of the amyloid-beta processing approaches at the oft-broken heart of current drug trials. The findings were published in the April 2, 2014, issue of Neuron. Senior author Ilya Bezprozvanny, who is at the University of Texas Southwestern Medical Center, told BioWorld Today that beyond their practical possibilities, the results support his contention that there is a lot more to AD than amyloid-beta.

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