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When Two Wrongs Make a Right

Statins Improve Outcomes of Rett Syndrome in Mice

By Anette Breindl
Science Editor

Tuesday, July 30, 2013
By applying an approach that is more commonly used in fruit flies and worms to mice, researchers have identified several new pathways that are disturbed in the autism spectrum disorder Rett syndrome. One of those pathways turned out to be cholesterol biosynthesis, and statins improved the symptoms of mice with Rett syndrome. The team identified the pathway through use of a so-called suppressor screen, a technique in which, essentially, two wrongs make a right.

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