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Tight timing improves drug combination effects

By Anette Breindl
Science Editor

Friday, May 9, 2014
"Sometimes," Paula Hammond told BioWorld Today, in basic research "you learn something that's very important, but then that's hard to replicate in patients." Such is the case, broadly speaking, for drug combinations. Everybody agrees they are the way of the future – indeed, in HIV, they are the way of the present, which is in no small part why the progress made in the fight against HIV is a modern medical miracle. But if the benefits of combination treatments can be more than the sum of their parts, so too can be the issues in developing them. One of the more mundane, but critical, aspects of combination treatments is that the relative timing of when two drugs are administered can be important for their synergies.

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