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Control Yourself!

Trials: Nobody's Perfect, Randomized Controlled or Not

By Anette Breindl
Science Editor

Friday, March 15, 2013

Randomized controlled trials are the gold standard of clinical research, and for good reason. They are "at the top of the evidence hierarchy. . . . They give us the most robust evidence," Caroline Sabin of University College London told the audience at a recent workshop on clinical trial design.

Both due to the randomization itself, and due to the presence of a control group, such trials give "very robust evidence" about an intervention's merits, she said.

But it's not always possible to do a randomized controlled trial.

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