Transflammation Critical to Transformation
Vector-Triggered Innate Immune Activity Is Necessary for iPSCs
By Anette Breindl
Wednesday, October 31, 2012
Researchers reported last week that the retroviral vector that is used for gene delivery in the generation of induced pluripotent stem cells, or iPSCs, does more than just ferry its cargo into cells. It activates the innate immune system and that activation is critical for efficient reprogramming.
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