The FDA's proposed rule on destroying drugs refused admission to the U.S. under the Federal Food, Drug and Cosmetics Act is set for publication in Tuesday's Federal Register. Authorized by the FDA Safety and Innovation Act, the rule would enable the FDA to destroy drugs, valued at $2,500 or less, after giving the owner or consignee notice and an opportunity to provide testimony prior to the destruction. The owner or consignee would be responsible for the cost of storage and destruction. The majority of refused drug products subject to the rule enter the U.S. via an international mail facility (IMF) or an express courier hub. The FDA estimates that 20 million to 100 million parcels of drugs are sent through an IMF to U.S. customers each year. Many of these may contain counterfeit or substandard drugs, and some may be marketed as supplements when they are actually unapproved drugs. Comments are due by July 5.