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THE BIOWORLD BIOME: Our Habitat for All Things Science

The zipper of death

The threat of drug-resistant superbugs is no secret, and neither is the fact that the development of new antibiotics faces commercialization challenges as well as scientific ones.

LONDON – A rapid, high-precision method for diagnosing sepsis by assessing the behavior of neutrophils in a single drop of blood was reported by researchers at Massachusetts General Hospital last week.

Why fiber matters

HONG KONG – A guild of gut bacteria that helped to alleviate the symptoms of type 2 diabetes mellitus (T2DM) in patients receiving a high-fiber diet, has been identified in a randomized clinical trial performed in China.

Collateral damage

LONDON - The first widespread screen assessing the effect of more than 1,100 marketed drugs on the human microbiome shows that 27 percent of those products inhibit the growth of at least one species of bacteria found in the gut.

'We've shown it can be done'

LONDON - The vision of two people given implants of retinal pigment epithelium (RPE) cells derived from human embryonic stem cells (hESCs) improved over the first year after receiving the patch.

Blocking the triple bypass

In cell lines directly generated from patients with anaplastic lymphoma kinase (ALK)-rearranged non-small-cell lung cancers that were resistant to second-generation ALK inhibitors, multiple different bypass resistance mutations ultimately converged on the same signaling mode to increase cell growth.

Researchers have defined five categories of diabetes patients, rather than the longstanding basic division into type 1 and type 2. That is an advance that could better enable health care providers to both combat the most aggressive forms of the disease as well as to help equip them to guide early treatment and prevention efforts in the lowest risk populations.

DIY beta cells

HONG KONG – Scientists at the Diabetes Research Institute (DRI) at the University of Miami Miller School of Medicine have for the first time confirmed the existence of human pancreatic progenitor cells and have shown they can be induced to develop into glucose-responsive pancreatic beta cells.

CROI 2018

BOSTON – Long-term control of HIV without the need for ongoing antiretroviral therapy (ART), even though it is not a cure, would be a major milestone for HIV treatment. At the Conference on Retroviruses and Opportunistic Infections (CROI) this week, researchers suggested that it may be possible to find treatments that induce such long-term control, through a combination of ART and broadly neutralizing antibodies (bNAbs).

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