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THE BIOWORLD BIOME: Our Habitat for All Things Science

Pre-eclampsia is one of the more frequent problems in pregnancy. It occurs in about 3 percent to 5 percent of pregnancy cases worldwide. Now, researchers at Nationwide Children's Hospital have shown that pre-eclampsia shares features with a disease that becomes a problem at the other end of the life span: Alzheimer's disease, and neurodegenerative disorders more generally.

PSYCHIATRY'S MANHATTAN PROJECT?
Psychiatry's net gains Tuesday: 108 new schizophrenia genetic loci and $650 million. The former were published in the July 22, 2014, online issue of Nature by the Schizophrenia Working Group of the Psychiatric Genomics Consortium, a collaboration of more than 300 scientists at dozens of institutions.
Defects in fatty acid-binding proteins (FABPs) may help to explain the pathology in some cases of schizophrenia and autism spectrum disorders (ASDs), possibly leading to the development of tailor-made therapies for those mental disorders, Japanese neuroscientists reported.
HONG KONG — Researchers here have elucidated a previously unknown signaling pathway involved in mediating the synaptic dysfunctions associated with Alzheimer's disease (AD) and have identified a promising new small-molecule disease-modifying intervention that may delay progress of the disease.
BREATHING ROOM
Successful organ transplantation starts with a race against time. When a donor organ becomes available, the current way to keep it going long enough for it to reach its lucky next owner is quite simple. It is flushed with a solution that was developed at the University of Wisconsin.
ENDING IMMUNODOMINANCE
The notion of a broad-spectrum T cell may, at first blush, sound like an oxymoron. The T and B cells of the adaptive immune system are, after all, best known for their exquisite specificity.
LONDON – Faults in the process by which cells in the brain remove debris may lie at the heart of several different neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis (ALS).
ZYFLO TO THE RESCUE?
As increasing bacterial drug resistance threatens to usher in a post-antibiotic era, one strategy being explored is so-called host-directed therapy – trying to give the immune system of an infected person a leg up against what ails them.
'CRACKS APPEARED IN THE EDIFICE'

LONDON – Nature has withdrawn two papers on so-called STAP cells, which claimed a method for stimulating any kind of adult cell to acquire pluripotency, but denied any fault in publishing them, saying, "We have concluded that we and the referees could not have detected the problems that fatally undermined the papers."

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