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THE BIOWORLD BIOME: Our Habitat for All Things Science

GET OUT AND DON’T COME BACK

Researchers have identified the signals that breast cancer cells use to get into the bone marrow, as well as the separate signals that keep them there. Disrupting those signals may offer a way to prevent late relapses of hormone-driven breast cancers.

CELL DEATH, SHAKEN OR STIRRED

HONG KONG – The in vivo antileukemic efficacy and safety of a novel combination of apoptosis-regulating drugs seen in a recent study by Australian researchers suggests that inhibition of apoptosis and activation of another type of cell death, necroptosis, warrants clinical investigation as a treatment for acute myeloid leukemia (AML).

EAT DIRT

Vaccination with a heat-killed soil bacterium both protected mice from colitis and protected them from the behavioral consequences of chronic stress, a team from the University of Colorado has found. The work potentially suggests “a way to lower risk for a number of diseases related to inappropriate inflammation,” Christopher Lowry told BioWorld Today.

HIV VACCINE

The degree of pre-existing adaptation between a person's immune system and the precise genetic characteristics of the HIV that person was infected with could predict how quickly disease would progress, researchers reported in the May 16, 2016, online issue of Nature Medicine. The paper addressed what co-corresponding author Jonathan Carlson termed a "deceptively simple" question – namely whether viral adaptation matters for the clinical course of infection.

ALL SORTS OF STEM CELLS

HONG KONG – A new study has demonstrated for the first time that nanomolar concentrations of a candidate cancer compound may also have therapeutic value in the field of stem cell therapy and tissue regeneration, Chinese researchers reported in the May 9, 2016, early online edition of Proceedings of the National Academy of Sciences.

THE BIOWORLD BIOME

In research spanning cell lines to humans, researchers have demonstrated that the hormone neurotensin is necessary for a high-fat diet to lead to obesity. Mark Evers, director of the University of Kentucky Markey Cancer Center, told BioWorld Today that neurotensin may be one of the links between obesity and an increased risk of cancer. The team reported its results in the May 12, 2016, issue of Nature.

PURPLE PUDDLES

An experimental Zika diagnostic can rapidly and inexpensively detect Zika virus and determine its specific strain, opening up the possibility of much improved monitoring of the virus as it spreads through the Americas.

SUGAR VS. CANCER

HONG KONG – A study by Taiwanese researchers has demonstrated that two glycoproteins are highly expressed in glioblastoma multiforme (GBM) cancer stem cells, and they play a key role in the tumorigenicity of the brain cancer. Both represent promising new potential therapeutic targets against the largely incurable disease.

ANGIOPOIETIN 2: THE EYES HAVE IT

HONG KONG – A recent study by scientists at the Department of Ophthalmology and Visual Sciences of the Faculty of Medicine at the Chinese University of Hong Kong (CUHK) has identified a potential new therapeutic target for age-related macular degeneration (AMD), which is the leading cause of central vision loss in the elderly.

Bench Press BioWorld looks at translational medicine


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