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THE BIOWORLD BIOME: Our Habitat for All Things Science

TARGETING MISS HOUSEKEEPING

A broad swath of KRAS-mutated non-small-cell lung cancers (NSCLCs) are sensitive to the effects of blocking nuclear export, offering a possible way to drug KRAS-mutant tumors, researchers reported in the Sept. 29, 2016, issue of Nature.

HACKING IMMUNITY

Researchers from the University of California at San Francisco reported that they have engineered T cells to both hone to targets of their choice, and set off gene expression programs of the researchers' choosing.

BEATING AMR IN A SNAPP?

HONG KONG – A structurally nanoengineered antimicrobial peptide polymer (SNAPP) showed great promise as an inexpensive but safe and effective antimicrobial, and may be a useful new weapon in the war against multidrug-resistant (MDR) gram-negative bacteria, an Australian study has found.

TAKING TISSUE TO THE BANK

HONG KONG – Retinal cells derived from the reprogrammed stem cells of one monkey have been transplanted into the eyes of others, without immune rejection and need for immunosuppressants, said researchers from the RIKEN Center for Developmental Biology (CDB) in Kobe, Japan.

STRENGTH IN NUMBERS

Preclinical work by researchers from Danish Orphazyme ApS has demonstrated that targeting heat-shock protein 70 (Hsp70) could alleviate a number of different lysosomal storage diseases, a group of several dozen rare to ultra-rare disorders united by mutations in proteins that lead to problems with cellular waste disposal.

THE ROAD TO NO NASHVILLE

As evidenced most recently by Allergan plc's purchase of Tobira Therapeutics Inc. and Akarna Therapeutics Ltd., nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) are getting a lot of love from the pharma industry these days, with good reason. (See BioWorld Today, Sept. 21, 2016.)

TRIMMING THE FAT

Inhibiting an enzyme that is important for fat synthesis led tumors to shrink in preclinical models of non-small-cell lung cancer, researchers reported in the Sept. 19, 2016, online issue of Nature Medicine.

BETTER THAN SEX

The behavioral effects of genetic mutations depend strongly on the mouse strain in which they are studied, and in some cases, the same genetic mutation can have opposite effects on behavior, such as increasing anxiety-driven behaviors in some mouse strains and decreasing them in others, researchers have found.

TEIXOBACTIN'S COUSINS

HONG KONG – Scientists at the University of Hong Kong (HKU) have successfully synthesized teixobactin, a recently discovered antibiotic that is considered to be a breakthrough in antibacterial drug research.

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