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‘Different from the ground up’

After a multiyear incubation period at Pfizer Inc., Springworks Therapeutics LLC sprang to life with four Pfizer-derived candidates and an oversubscribed $103 million kitty to see them to the next stage of development. more »


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ApoE, tau interact directly in Alzheimer's disease

ApoE variants are the strongest known genetic risk factor not just for Alzheimer's disease (AD), but for any disease. It was first described just about 25 years ago. "And I've worked on it since then," David Holtzman told BioWorld.

In those 25 years, it has become clear that individuals with at least one copy of the ApoE4 variant, rather than ApoE3 or the protective ApoE2, have drawn the short stick in pretty much every aspect of the disease. They are more likely to develop AD in the first place, they do so at a younger age, and the disease progresses more quickly.

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