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Healthy correction in August

The fears that the downward spiral of the capital markets during the financial crisis that occurred in 2008 would be repeated in the wake of last week's "Black Monday" are, for the time being, in the rearview mirror. more »

Our Habitat for All Things Science
No brainer: FTO's effects on weight are peripheral effect

In genomewide association studies (GWAS), a variant in the gene FTO is the strongest obesity-correlated signal in the human genome.

Since it was first flagged by GWAS seven years ago, though, why FTO is so strongly linked to obesity has remained a puzzle.

Now, scientists have dissected the cellular circuitry that is affected by FTO. Their work both suggests new obesity targets and could serve as a general roadmap for how to understand the effects of variants in noncoding regions of the genome.