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Program could provide a 'great advance'

Ironwood Pharmaceuticals Inc. is kicking off twin phase III trials of a specially formulated bile acid sequestrant developed to help people with uncontrolled gastroesophageal reflux disease (GERD) minimize symptoms of the ailment, such as heartburn. 

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Ibrutinib could be repurposed to treat glioblastoma

HONG KONG – Preclinical data from a Sino-US study suggest that a tyrosine kinase inhibitor originally developed to treat lymphoma and leukemia, Imbruvica (ibrutinib, Abbvie Inc./Johnson & Johnson), could also target glioma stem cells (GSCs), effectively controlling glioblastoma growth.

Despite therapeutic advances in other solid tumors, glioblastoma remains the most lethal primary brain tumor. It is highly resistant to current treatments including radiotherapy and chemotherapy. The cancer usually recurs rapidly, with a median survival of less than 15 months from diagnosis.

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