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Half their size!

Researchers at Boston Children's Hospital have used a novel type of screening to identify a compound that caused massive weight loss in mice with diet-induced obesity, causing them to lose 45 percent of their body weight. more »


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Search for painkillers comes half-circle

A genomics-based search for better drug targets for painkillers has turned up a candidate that is, in one sense, not new at all.

That candidate is the nicotinic acetylcholine receptor, already the beneficiary of one failed round of drug development.

But the new study, which was published in the May 13, 2015, issue of Science Translational Medicine, suggests that targeting a different subunit of the receptor, and doing so in the periphery, may yield better clinical results.

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