Login to Your Account

A 4-letter naming scheme

What's in a name? A core drug substance and a four-letter alphabet soup suffix. That's the FDA's proposal for nonproprietary, or "proper," names for reference biologics and biosimilars. 

more »

Our Habitat for All Things Science
No brainer: FTO's effects on weight are peripheral effect

In genomewide association studies (GWAS), a variant in the gene FTO is the strongest obesity-correlated signal in the human genome.

Since it was first flagged by GWAS seven years ago, though, why FTO is so strongly linked to obesity has remained a puzzle.

Now, scientists have dissected the cellular circuitry that is affected by FTO. Their work both suggests new obesity targets and could serve as a general roadmap for how to understand the effects of variants in noncoding regions of the genome.