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PERSISTence fails to prevail

Prospects for Durect Corp.’s Posimir (Saber-bupivacaine) dimmed dramatically with the late Thursday disclosure of a failed phase III study of the extended-release analgesic. more »


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BRCA1 function compromised in Alzheimer’s disease

The BRCA genes were first discovered for their roles in gynecological cancers, with the most deleterious mutations in BRCA1 and BRCA2 raising a woman’s lifetime risk of breast or ovarian cancer from 7 percent to somewhere between 45 and 65 percent.

But BRCA’s role is less sex-specific than its strong association with gynecological cancers would suggest. Both BRCA1 and BRCA2 play a role in repairing DNA damage, a function that is important in all cell types.

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