With FDA approval secured for Rigel Pharmaceuticals Inc.'s Tavalisse (fostamatinib), company backers sought details about price and positioning, but heard they must wait for answers.

CHICAGO – With blocking the PD-1 pathway working so well in so many tumor types, a seemingly never-ending number of companies are taking an "if you can't beat 'em, join 'em" approach, adding their therapies to anti-PD-1/PD-L1 drugs.

CHICAGO – PD-1 drugs in lung cancer took over the second day of the American Association for Cancer Research meeting with a trio of presentations of clinical trials in patients with non-small-cell lung cancer (NSCLC), which were all concurrently published in The New England Journal of Medicine.

PARIS – Biopsy data from a subgroup of patients enrolled in Intercept Pharmaceuticals Inc.'s phase III POISE study of Ocaliva (obeticholic acid, or OCA) for the treatment of primary biliary cirrhosis (PBC) confirmed stabilization or regression of fibrosis/cirrhosis in 85 percent of the cohort following three years of treatment.

- Denovo kicks off phase III biomarker-driven trial in DLBCL; doses first patient in China
- Unauthorized FDCs in cross-hairs of India's CDSCO
- Australia's life sciences sector braces for battle over looming budget
- Partnering wave still cresting, no splash for M&A transactions
- Platelets, antibodies form anaphylaxis alliance


Despite the fact that the industry inked more than 1,000 deals last year, it appears that biopharma companies are not losing their appetite for dealmaking. According to data from BioWorld and Cortellis Deals Intelligence, there were 271 deals signed in the first quarter of 2018, on par with 2017 first quarter transactions.
A study has identified common genetic variants in the Chinese population contributing to the risk of developing Alzheimer's disease (AD) that possibly exert functional effects through the immune system, which could have important implications for AD management.
The search continues for promising biomarkers and effective disease-modifying therapies for AD. The current drug development approaches mainly target the disease's hallmark pathology of amyloid-beta (Abeta) protein accumulation in the brain leading to Abeta plaque deposition.
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- New approaches could broaden antibiotic space »
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- New approaches could broaden antibiotic space »

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