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First human gene knockout

LONDON – Scientists in the U.K. are laying claim to the creation of the first human gene knockout after using CRISPR/Cas 9 to delete the gene encoding for the transcription factor Oct4, in day-old embryos.

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Analysis

While advocacy to raise awareness about mitochondrial diseases around the world is ongoing, these efforts get a boost each year during the third week of September, which is dedicated to Mitochondrial Disease Awareness Week. Its aim is to increase the spotlight on the need for more research to uncover new therapies. 

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Nuclear factor controlling brown fat gene identified

A study reported Aug. 14, 2017 in Nature Cell Biology has identified a nuclear factor involved in brown fat metabolism that contributes to the pathophysiology of obesity in humans, which could lead to the development of new brown fat-targeted anti-obesity therapies.

The world's population is experiencing an epidemic of obesity and complications including diabetes and atherosclerosis. The World Health Organization estimates that global obesity more than doubled between 1980 and 2014, with almost 2 billion adults being overweight in 2015.

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