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One of the major current goals of cancer immunotherapy research is to learn to predict who will benefit from it, and why, with the aim of broadening its successes. more »

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Nanoparticle quells inflammation in sepsis and ARDS

Researchers at Queens University Belfast have developed a nanoparticle that could dampen inflammatory responses and improve survival in animal models of both sepsis and acute respiratory distress syndrome, both major causes of death and disability in hospitalized patients.

The particles consist of a specific type of sialic acid coated onto poly(lactic-co-glycolic acid) (PLGA) nanoparticles that target siglec-E, a surface receptor that is important for dampening the inflammatory responses of macrophages.

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