Omeros Corp., of Seattle, said research on mannan-binding lectin-associated serine protease-2 (MASP-2) published in the Proceedings of the National Academy of Sciences showed blocking MASP-2 function significantly reduced tissue damage caused by ischemia-reperfusion injury. Researchers showed that, in animal models of cardiac and gastrointestinal ischemia-reperfusion injury, inhibition of MASP-2 function blocked the excessive inflammatory responses, resulting in less tissue damage.