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MediciNova Inc., of San Diego, and Zhejiang Medicine Co. Ltd., of Hangzhou, China, signed a letter of intent to form a joint venture to develop and commercialize MediciNova's MN-221 in China. Financial terms were not disclosed. MN-221, a selective, beta2-adrenergic receptor agonist, is in development in acute exacerbations of asthma and chronic obstructive pulmonary disease.