Readying for a phase II in the third quarter with Karxt, its combo drug for schizophrenia, Karuna Pharmaceuticals Inc. aims to capitalize on data gained previously by licensor Eli Lilly and Co. with the muscarinic acetylcholine receptor agonist xanomeline as well as historic findings with trospium chloride, a muscarinic receptor antagonist approved by the FDA in 2004 for overactive bladder.