• Valeant Pharmaceuticals International Inc., of Mississauga, Ontario, said it mailed its offer and takeover bid to shareholders of Afexa Life Sciences Inc., of Edmonton, Alberta. Last month, Valeant made the offer to acquire Afexa for C71 cents (US73 cents) per share, or C$76 million, which trumped an earlier bid by Montreal-based Paladin Labs Inc. Valeant's offer expires at 5 p.m. (Edmonton time) Oct. 17, 2011.