In a major setback for the soft tissue sarcoma (STS) space – a complex disease with a dearth of treatment options – Eli Lilly and Co. said the confirmatory phase III ANNOUNCE study of Lartruvo (olaratumab) in combination with doxorubicin failed to meet the primary endpoints of overall survival (OS) in the full study population in advanced or metastatic STS or in the leiomyosarcoma (LMS) subpopulation.