October 12 (WO)
Adherex Technol. WO 00/59939
Inhibiting _-catenin degradation
Modulating agents for inhibiting degradation of cytoplasmic _-catenin; for stimulating cell differentiation.
Alton Ochsner Med. Fdn. WO 00/60127
Identification of a retrovirus associated with Crohn's disease and ulcerative colitis.
AstraZeneca WO 00/60062
Serine/threonine protein kinase
Human signal transduction serine/threonine protein kinase, encoding gene sequences, antisense; for therapeutics.
Biocrystal WO 00/59540
Immune complex-mediated activation
Assays for biological responses inducible by activation of Fc-gamma-RI-expressing cells by shed antigen complexes.
Biomerieux WO 00/60049
Ultrasonic cell lysis
Marcy l'Etoile, France
Methods an devices for the ultrasonic lysis of biological cells; for preserving cellular DNA.
Bioniche Life Sciences WO 00/59518
Prostate cancer therapy
Mycoplasm DNA complexed with cell wall material; for inducing apoptosis in prostate cancer cells.
Borstel Res. Ctr. WO 00/59943
Monoclonal antibodies to human Mcm3, hybridomas; for diagnostics and therapeutics.
Brigham & Women's Hosp. WO 00/60055
Dendritic cells modified to express a selectin polypeptide; for delivery to lymph nodes to stimulate immunoresponses.
California, Univ. of WO 00/59936
Human neurogenin 3-encoding gene sequences, encoded protein, antibodies; for identifying _-cells and treating diabetes.
California, Univ. of WO 00/60109
Measuring the amplification state of the CYP24 gene; for cancer prognosis and diagnosis.
Canadian Ministry of Health WO 00/59944
Breast cancer antibodies
Monoclonal antibodies to estrogen-stimulated leucine aminopeptidase; for measuring levels in breast cancers.
Canbreal Therodiagnostics WO 00/60357
Breast cancer diagnostics
Monoclonal antibodies to several markers associated with breast cancer; for tandem diagnostic immunoassays.
Cantab Pharma Res. WO 00/59927
Purifying biological molecules
Methods for reducing contaminant content in biological preparations of recombinant proteins from bacteria.
Ceptyr WO 00/60092 & 60098-60100
Dual-specificity phosphatases, encoding gene sequences; for modulating cell proliferation and differentiation.
Children's Hosp. WO 00/59533
Autoimmune disease therapy
Use of asparaginase and glutaminase to treat autoimmune and graft versus host disease.
Chiron WO 00/60079
TNF superfamily proteins
Tumor necrosis factor (TNF) and TNF receptor superfamily proteins, encoding genes; for identifying modulators.
Chiron WO 00/60083
Stress-phosphorylated ER protein
Endoplasmic reticulum (ER) protein whose phosphorylation is induced by stress, encoding gene sequences.
City of Hope WO 00/60115
Accessible RNA binding sites
Methods for identifying sites on target RNA that are accessible to pairing by antisense and ribozymes.
Cold Spr. Harbor Labs WO 00/60078
Cold Spr. Harbor, N.Y.
Human latheo, encoding gene, antibodies, antisense; for identifying cognitive dysfunction therapeutics.
Connolly, D.M. WO 00/60125
DNA detection methods
High resolution DNA detection methods and devices using oligonucleotide probes integrated into electrical circuits.
Corixa WO 00/60076
Breast cancer proteins
Breast cancer proteins, immunogenic fragments, encoding gene sequences; for diagnostics and therapeutics.
Corixa WO 00/60077
Lung cancer proteins
Lung cancer proteins, immunogenic fragments, encoding gene sequences; for diagnostics and therapeutics.
Corixa WO 00/60084
Prostate cancer proteins
Prostate cancer proteins, encoding gene sequences, antibodies; for diagnostics and therapeutics.
Corixa WO 00/60090
Bacillus microti antigens, encoding gene sequences, antibodies; for infection treatment and vaccines.
CuraGen WO 00/60066
Protein binding disruption
New Haven, Conn.
Protein-protein complexes from yeast cells; for identifying compounds that disrupt the binding interaction.
Eli Lilly WO 00/59942
hOB-BP2h polypeptides, encoding gene sequences, chimerics, antibodies, transgenics, production methods.
European Molec. Biol. Lab WO 00/60071
Microtubule-associated protein TPX2; for modulation of mitosis.
Gene Logic WO 00/60122
Ischemic heart genes
Identification of a gene whose expression is increased in ischemic heart tissue.
Genentech WO 00/59525
S. San Francisco
Use of ErbB receptor ligands, including antibodies, to treat diabetes or pancreatic cells for implant.
Genetics Inst. WO 00/59938
Angiopoietin-like proteins, Crisp proteins, encoding gene sequences; for diagnostics and therapeutics.
Genome Technologies WO 00/60121
PCR-based amplification techniques for genome walking using synthetic primers.
Genome Technologies WO 00/60123
Methods for selecting primers for PCR-based amplification of nucleic acids.
Harrington Arthritis Res. Ctr. WO 00/59297
Transgenics with Alzheimer's-like activity in the posterior cingulate region of the brain; for identifying therapeutics.
Hisamitsu Pharma WO 00/60068
Therapeutics from squamous cells
Regulatory gene sequences that cause squamous cell-specific expression; for therapeutic production from these cells.
Icos WO 00/60355
LFA-1 ICAM binding site
LFA-1 regulatory binding site for intercellular adhesion molecule (ICAM); for modulating interactions.
Incyte Genomics WO 00/60080
Immune system proteins
Palo Alto, Calif.
Human immune system proteins, encoding genes, antibodies, modulators; for diagnostics and therapeutics.
Incyte Genomics WO 00/60082
Palo Alto, Calif.
Vesicle-associated proteins, encoding gene sequences, antibodies, modulators; for diagnostics and therapeutics.
Innogenetics WO 00/60070
Protein carrying scaffold
Polypeptide chain having a _ sandwich architecture; for use as a scaffold to carry antigen-binding fragments.
INRA (Natl. Agron. Res. Inst.) WO 00/60094
Oxidant stress protectant
Modified lactococci that express a heterologous catalase; for protecting cells from oxidant stress.
Isis Pharma WO 00/59474
Lipids that are fusogenic for cell membranes; for liposomal delivery of therapeutics.
Isis Pharma WO 00/59549
Antisense oligonucleotides to Jun N-terminal kinase (JNK); for inducing apoptosis.
Isis Pharma WO 00/59919
p38 MAPK antisense
Antisense oligonucleotides to p38 mitogen-activated protein kinase (MAPK); for disease treatment.
Japan Sci. & Technol. WO 00/60074
Dendritic cell-expressed genes
Genes that are highly expressed in human dendritic cells, encoded proteins; for diagnostics and therapeutics.
Japan Tobacco WO 00/60075
G-CSF antibody antigen
Gene encoding an antigen recognized by G-CSF inductive antibody, encoded protein.
Japanese Ind. Res. & Technol. Agency WO 00/60096
Aminotransferase that is stable at high temperatures and over a wide pH range.
Johns Hopkins Univ. WO 00/59538
Autoimmune disease therapy
Antigen-specific induction of immune tolerance using Fas ligand-myelin basic protein; for autoimmune disease therapy.
Kudos Pharma WO 00/60359
Ku polypeptide interactions
Interactions of Ku polypeptides; for developing therapeutics to modulate various cellular processes.
Lions Eye Inst. WO 00/60067
Cathepsin D gene promoter
Cathepsin D gene promoter and regulatory element; for expression vector construction and gene expression control.
Mass. Gen. Hosp. WO 00/59941
Migratory cell movement
Modulating movement of human migratory cells in tumor and pathogenic infection sites.
Max Planck Inst. WO 00/60054
Collateral artery growth
Monocytes loaded with therapeutically active molecules; for inducing growth of collateral arteries.
Mayo Clinic WO 00/59935
Anti-apoptotic fusion polypeptides; for inhibiting apoptosis.
McGill Univ. WO 00/60113
Methods for using a transposon-based genetic marker to detect gene polymorphisms.
Medical Biosystems WO 00/60072
Polynucleotide synthesis using a processing enzyme whose conformation modulation allows nucleotide incorporation.
Medical Biosystems WO 00/60114
Polynucleotide sequencing using an immobilized helicase-primase enzyme.
Merck WO 00/60106
Adenoviral vector gene therapy
Methods for using helper-dependent recombinant adenoviral vectors of alternative serotypes; for repeated gene therapy.
Millennium Pharma WO 00/60085
Fibroblast growth factor (FGF)-20, encoding gene sequences, antibodies, transgenics; for diagnostics and therapeutics.
Monsanto WO 00/60103
Protein production system
Linkage of heterologous structural genes to a cyanobacteria gene promoter; for expression of recombinant proteins.
Mortimer Davis Jewish Gen. Hosp. WO 00/60126
Gene expression patterns
Quantitative assay for gene expression patterns in deformable large-scale microarrays.
Mosaic Technologies WO 00/60120
Immobilized nucleic acid capture probes; for detecting bacteria in samples and finding gene mutations.
Neurotech WO 00/60051
Non-tumorigenic, non-immunogenic human cell line ARPE-19; for use in encapsulated cell-based delivery systems.
New York, State Univ. of WO 00/59537
Recombinant protein secretion
Bacterial signal sequences, encoding gene sequences; for fusion to heterologous proteins for efficient secretion.
Novo Nordisk WO 00/60058-60060
Alkaline a-amylase activity
Proteins having alkaline a-amylase activity, variants, encoding gene sequences, production methods.
Novo Nordisk WO 00/60063
Lipase variants, encoding gene sequences; for diagnostics and therapeutics.
Oklahoma Med. Res. Fdn. WO 00/60091
Cre recombinase variants
Methods of selecting Cre recombinase variants having a broadened specificity for the site of recombination.
Osiris Therapeutics WO 00/59933
Mesenchymal DNA fingerprinting
Human mesenchymal DNAs and expression products derived from open reading frames, antibodies; for DNA fingerprinting.
Proctor & Gamble WO 00/60064
Purification process for a calcium-binding metalloprotease using calcium-free buffer.
Ramot Univ. WO 00/60110
Bacterial infection detection
Ramat Aviv, Israel
Monitoring bacterial gene expression by electrochemical means; for detecting infection.
Rauche, H. WO 00/59917
Information-carrying and -processing polymers; for polymeric memories and DNA computers.
Schering WO 00/60107
Cholesterol lowering agents
Stereoselective reduction of a substituted azetidinone by bacteria; for producing serum cholesterol lowering agents.
SmithKline Beecham WO 00/59514
Bacterial yeaZ proteins, encoding genes, recombinant production methods; for antibacterial screens.
SmithKline Beecham WO 00/59529
Mouse EDG1 gene
Mouse EDG1 gene, encoded protein, recombinant production methods; for diagnostics and therapeutics.
SmithKline Beecham WO 00/59923
Regulator proteins, encoding gene sequences, recombinant production methods; for diagnostics and therapeutics.
SmithKline Beecham WO 00/60056
Mouse EDG5 gene
Mouse EDG5 gene, encoded protein, recombinant production methods; for diagnostics and therapeutics.
SmithKline Beecham WO 00/60057
Rat GPR10 gene
Rat GPR10 gene, encoded protein, recombinant production methods; for diagnostics and therapeutics.
SmithKline Beecham WO 00/60104
Rat KIAA0001 gene
Rat KIAA0001 gene, encoded protein, recombinant production methods; for diagnostics and therapeutics.
SmithKline Beecham WO 00/60105
Bacterial murA proteins, encoding genes, recombinant production methods; for antibacterial screens.
Sumitomo Pharma WO 00/60073
Gene whose expression is induced by p53 inactivation, encoded protein; for cancer diagnostics and therapeutics.
Synaptic Pharma WO 00/60081
Orphan G protein-coupled receptor
DNA encoding an orphan G protein-coupled receptor, encoded protein; for diagnostics and therapeutics.
Thomas Jefferson Univ. WO 00/59526
Peptides conjugated to lipophilic moieties; for enhancing cellular uptake in order to modulate apoptosis.
Toronto, Univ. of WO 00/60069
Presenilin-associated membrane protein, encoding gene sequences; for Alzheimer's diagnostics and therapeutics.
Tropix WO 00/60116
High-throughput, high-sensitivity assays requiring little purification that have amplification to maximize signals.
Utah, Univ. of WO 00/59918
Antibacterial drug development
Salt Lake City
Eubacterial tmDNA sequences and corresponding tmRNA sequences; for developing antibacterial drugs.
Victoria, Univ. of WO 00/60102
Presenting foreign peptides
Salmonella strains having heterologous fimbrin genes; for presentation of foreign peptide sequences.
Walters, R.E., et al. WO 00/60065
Tangential flow cell concentration and fusion apparatus; for cell electrofusion.
Wisconsin, Univ. of WO 00/60050
Recombinant influenza viruses free of helper viruses; for preparing vaccines.
Yale Univ. WO 00/60124
New Haven, Conn.
Fixed address analysis of sequence tags by sorting tags by their sticky ends; for nucleic acid fingerprinting.
Zeneca Mogen WO 00/60086
Pathogen-inducible promoter; for making vectors in which a therapeutic structural gene is linked to this promoter.
ZymoGenetics WO 00/59934
Testis-specific protein, encoding gene sequences; for diagnosing, staging, and treating cancer.