Published March 8 (EPO); March 2 (WO); March 8 (GB)
Abbott Labs WO 00/12720
Abbott Park, Ill.
Elongase genes involved in the elongation of polyunsaturated acids; for production.
Antex Biologics WO 00/12133
Neisseria proteins, encoding gene sequences, antibodies; for inducing an immune response.
Antex Biologics WO 00/12535
Neisseria meningitidis NMASP polypeptides, encoding gene sequences, antibodies; for meningitis vaccines.
Aventis Pharma WO 00/12738
Targeting adenoviral vectors
Adenovirus vectors having modified fiber and hexon proteins; for targeting heterologous genes to specific tissues.
BASF WO 00/12739
Liver gene therapy
Methods and compositions for expressing heterologous genes in liver cells using hepadnaviral vectors; for gene therapy.
BASF WO 00/12748
Microorganisms having inserted genes for riboflavin synthesis; for riboflavin production.
Bavarian Nordic Res. Ctr. WO 00/12737
Cell differentiation marker
Guanylate binding protein as an inhibitor of cell proliferation and marker of cell differentiation.
Bayer WO 00/12702
Colorectal cancer diagnostics
East Walpole, Mass.
Human genes differentially expressed in colorectal cancer, variants, encoded proteins, antisense, antibodies.
Becton Dickinson EPO 985 931
Franklin Lakes, N.J.
Detection of antibodies to Troponema pallidum, fusion protein antigens; for diagnosing syphilis.
Biotech & Genetic Engineer. Ctr. EPO 985 729
Streptokinase mutants that retain plasminogen activator complex formation activity but have less antigenicity.
Boehringer Ingelheim WO 00/12696
Uncoupling protein 3 promoters
Cell-specific promoters of uncoupling protein 3 expression; for high-throughput modulator screens.
Boston Univ. WO 00/12544
IRAP binding proteins
IRAP binding proteins, fusions, antigenic peptides, antibodies, transgenics; for diagnostics and therapeutics.
British Columbia, Univ. of WO 00/12528
Anti-endotoxic antimicrobial cationic peptides; for treating respiratory infections and accelerating wound healing.
Canag Diagnostics WO 00/12559
Monoclonal antibodies against the calcium binding protein S100; for isoform immunoassays.
Cedars-Sinai Med. Ctr. WO 00/12710
Ataxin-2 binding protein
Ataxin-2 binding protein gene, encoded ptotein, antisense, antibodies, transgenics; for diagnostics and therapeutics.
Chugai WO 00/12749
Sterol regulation inhibitors
Methods for screening sterol regulatory element binding protein pathway inhibitors; for therapeutics.
Chugai Inst. Molec. Med. WO 00/12712
Nerve differentiation factor
Nerve differentiation factor, encoding gene sequences; for diagnostics and therapeutics.
Danisco GB 2 341 391
UDP-galactose epimerase, encoding gene sequences; for diagnostics and therapeutics.
Dendreon WO 00/12560
Tumor cell apoptosis
Human MHC class II, HLA-DR-specific antibodies; for inducing apoptosis in HLA-DR antigen positive tumor cells.
Desmos WO 00/12690
Laminin for bone growth
Administration of laminin 5 in combination with other osteogenic and angiogenic factors; for bone growth.
Diacrin WO 00/12138
Immune rejection reduction
Cells expressing immunoregulatory molecules that inhibit T cell activation; for reducing immune rejection.
Diadexus WO 00/12761
Baldder cancer antibodies
Santa Clara, Calif.
Antibodies to bladder cancer antigens; for diagnosing, imaging, staging, monitoring, and treating bladder cancer.
Duke Univ. WO 00/12740
Adenoviral vectors with deletions in IVa2, 100K, polymerase, or preterminal protein regions; for gene therapy.
Eli Lilly WO 00/12117
Wnt homolog proteins, encoding gene sequences, antibodies, transgenics; for diagnostics and therapeutics.
Eli Lilly WO 00/12532
Factor VIII homologs
Factor VIII homologs, encoding gene sequences, antibodies, transgenics, production methods; for therapeutics.
Eli Lilly WO 00/12551
TGF-b binding protein
Human latent transforming growth factor (TGF)-b binding protein 3, encoding gene; for finding TGF-b inhibitors.
Fuso Pharma WO 00/12691
Hepatitis C diagnostics
Enhancer sequences; for potentiating the expression of genes and diagnosing hepatitis C.
Gene Logic WO 00/11942
Ischemic heart gene
Human gene differentially expressed in ischemic heart tissue; for cardiac disease diagnostics and therapeutics.
Genentech WO 00/12562
Factor IX/IXa antibodies
S. San Francisco
Human anti-Factor IX/IXa antibodies, encoding gene sequences, fragments; for therapeutics.
Genentech WO 00/12708
S. San Francisco
Pro-polypeptides from receptor and membrane-bound proteins, encoding genes, fusions, antibodies; for therapeutics.
Genoclipp Biotech WO 00/12725
Gene encoding amorpha-4,11-diene sythase; for transfection into cells and production of artemisinin.
Genoplex WO 00/12764
Comparison of human and primate gene sequences using statistical methods; for finding AIDS-related genes.
Genvec WO 00/12765
Gene therapy vector purity
Determination of viral gene transfer vector stock purity using mass-to-charge ratio methods on fragmented samples.
Hawaii Biotech Group WO 00/12128
Recombinant flavivirus nonstructural protein fused to a truncated envelope protein; for vaccines and diagnostics.
Hayashibara Seibutsu WO/12555
IL-18 binding protein
Interleukin (IL)-18 binding protein, encoding gene sequences, regulators; for immunotherapeutics.
Hong Kong, Univ. of WO 00/12677
Bursal disease virus vaccine
Site-directed mutagenesis of recombinant infectious bursal disease virus; for attenuated vaccines.
Human Genome Sciences WO 00/12678
Staphylococcus aureus genes, encoded proteins, production methods; for diagnostics and therapeutics.
Incyte Genomics WO 00/12685
Neurotransmitter processing genes
Palo Alto, Calif.
Genes associated with neurotransmitter processing, encoded proteins, antibodies, modulators; for therapeutics.
Incyte Genomics WO 00/12703
Protein transport molecules
Palo Alto, Calif.
Protein transport-associated proteins, encoding genes, antibodies, modulators; for diagnostics and therapeutics.
Incyte Genomics WO 00/12711
Membrane channel proteins
Palo Alto, Calif.
Human membrane channel proteins, encoding gene sequences, antibodies, modulators; for diagnostics and therapeutics.
INSERM (Natl. Inst. Hlth. & Med. Res.) WO 00/12742
Transfer of male germ cell promoter controlled Cre-mediated recombinase into oocytes; for genome remodeling.
Inst. Hormones & Plant Res. WO 00/12697
Bovine estrogen receptor-b, fragments, encoding gene sequences; for identifying modulators.
Invitrogen WO 00/126787
Cell-free cloning system having site-specific recombination sequences; for rapid recombinase-mediated subcloning.
Isis Pharma WO 00/12527
Antisense oligonucleotides for modulating TRADD expression; for diagnostics and therapeutics.
Itoh, K., et al. WO 00/12701
SART-3 tumor antigen
Tumor antigen SART-3, peptides, derivatives, encoding gene sequences; for diagnostics and therapeutics.
Japanese Ind. Sci. & Tech. Agency WO 00/12686
Systems for expressing functional nucleic acids such as ribozymes.
Kao EPO 985 731
Mutated a-amylases having alkaline pH optima and tolerance to oxidizing agents.
KS Biomedix WO 00/12556
High affinity antibodies
High affinity monoclonal antibodies, methods for immunoassays using these antibodies.
Kyowa Hakko Kogyo WO 00/12550
Transporter polypeptide, encoding gene sequences, antibodies; for identifying ligands.
L-Huillier, P.J., et al. WO 00/12552
Mammary-specific transcription factor
Hamilton, New Zealand
Mammary-specific transcription factor BrEts, encoding gene; for breast cancer diagnostics and therapeutics.
Mass. Inst. Technol. WO 00/12726
Rationally designed heparinases derived fron heparinase I and II, encoding gene sequences; for therapeutics.
Microbiol. Res. Authority WO 00/12718
Meningococcal infection vaccine
Superoxide dismutase, encoding gene sequences, antibodies; for eliciting immunity to meningococcal infections.
Millennium Biotherapeutics WO 00/12707
G-protein coupled receptor
14926 G-protein coupled receptor, encoding gene; for modulator identification, diagnostics, and therapeutics.
Millennium Pharma WO 00/12762
TANGO 130 genes, encoded protein related to melanoma-inhibiting protein, antigens, antibodies, transgenics.
Monash Univ. WO 00/12695
Tumor transcription modulators
ELF5, a member of the ETS protein family, encoding gene, antibodies; for modulating transcription in tumors.
Myriad Genetics WO 00/12694
Prostate cancer gene
Salt Lake City
Chromosome 1-linked prostate cancer susceptibility gene, splice variants; for multisite tumor suppression.
NIH (Natl. Inst. Hlth.) WO 00/12706
Reproductive tissue protein
PAGE-3 gene which is preferentially expressed in normal reproductive tissues; for inhibiting cancer growth.
New England Biolabs EPO 985 730
SnaB1 restriction enzyme
SnaB1 methylase gene from Sphaerotilus natans, production and purification methods; for DNA digestion.
New York, State Univ. of WO 00/12546
Mammalian elk potassium channel
Mammalian elk potassium channel, encoding gene sequences; for identifying modulators.
New York Univ. WO 00/12679
Ubiquitin ligases, encoding gene sequences, transgenics; for cancer diagnostics and therapeutics.
New York Univ. WO 00/12683
Pluripotent stem cells
Pluripotent stem cells with a fibroblast growth factor receptor on cell surfaces.
Nexstar Pharma WO 00/12530
Site-directed covalent conjugation of deoxyuridine to selected moieties.
North Carolina, Univ. of WO 00/12693
Shuttling large DNA inserts
Chapel Hill, N.C.
Recombinant herpes virus-based plasmid for producing large-insert episomes; for shuttling large genomic DNA inserts.
Ontario Cancer Inst. WO 00/12719
Acute leukemia gene
CDC2-related kinase associated with acute leukemia, encoding gene sequences; for diagnostics and therapeutics.
Pan Pacific Pharma GB 2 341 389
Bee venom protein
Menlo Park, Calif.
Bee venom protein, encoding gene sequences, antibodies; for treating inflammatory diseases.
Pausch, M.H., et al. WO 00/12704 & 12705
G protein-coupled receptors
Constitutively active mutant heterologous G protein-coupled receptors; for enhanced functional expression.
Pittsburgh, Univ. of WO 00/12545
Bladder nuclear matrix proteins
Bladder nuclear matrix proteins, encoding gene sequences; for cancer diagnostics and therapeutics.
Princeton Univ. WO 00/12526
Modulating cell growth
Identification of p53-induced and -repressed target genes; for modulation of cell proliferation.
Promega WO 00/12728
Expression and production of clostridial toxins and proteins in bacteria; for vaccines and neurological therapeutics.
Quark Biotech WO 00/12139 & 12525
Hypoxia-regulated genes, encoded proteins; for identifying neuroprotective agents.
Roche Diagnostics WO 00/12558
Islet cell antibodies
Human monoclonal antibodies against islet cell antigen IA-2, production methods; for detecting islet cell antigens.
Rochester, Univ. of WO 00/12763
PSA regulatory sequences
Regulatory sequences of prostate specific antigen (PSA); for transgenics and controlling heterologous gene expression.
Schering WO 00/12543
Farnesyl protein transferase
Crystalline farnesyl protein transferase, substrate and inhibitor complexes; for structural determinations.
Shionogi WO 00/1277700
CDw108 protein, encoding gene sequences, antisense, antibodies; for diagnostics and therapeutics.
SmithKline Beecham WO 00/12105
RAMP2a protein, encoding gene sequences, recombinant production methods; for diagnostics and therapeutics.
SmithKline Beecham WO 00/12106
GABA B1AA receptor
GABA B1AA receptor, encoding gene sequences, recombinant production methods; for diagnostics and therapeutics.
SmithKline Beecham WO 00/12531
RatC polypeptides, encoding gene sequences, recombinant production methods; for antibacterial screens.
Synaptic Pharma WO 00/12692
GABABR2 receptor, encoding gene, antisense, antibodies, transgenics; for modulator screens.
Taiho Pharma WO 00/12561
Thymidylate synthase antibodies
Anti-human thymidylate synthase monoclonal antibodies, production hybridoma cells; for immunoassays.
Terumo EPO 985 732
Trimeric chimera protein containing collagen fused to a biologically active peptide; for fibril formation.
Transgene WO 00/12741
Adenoviral vectors with heterologous genes inducible by inserted transcriptional activator genes; for therapeutics.
Trinity Coll. WO 00/12689
Cell wall-associated coagulase-negative staphylococcal proteins, encoding genes; for vaccines.
Urogenesys WO 00/12709
Prostate cancer protein
Santa Monica, Calif.
Helix-loop-helix protein highly expressed in prostate cancer, encoding gene; for diagnostics and therapeutics.
Vertex Pharma WO 00/12727
Protease inhibitor assay
Fusion proteins for measuring protease activity, encoding gene sequences; for finding protease modulators.
Wisconsin, Univ. of WO 00/12682
Primate transplantation cells
Primate embryonic stem cells that are MHC-matched to specific recipients; for transplantation.
Worldwide Medical WO 00/12529
Assay for anti-sperm antibodies to infertility-associated sperm antigens; for modulating fertility.
Yeda Res. & Develop. WO 00/127699
Transcription factor TAFIID subunit, modified fragment, encoding gene sequences; for modulating apoptosis.
Yu, L., et al. WO 00/12717 & 12721-12723
Lysozyme family gene
Human lysozyme family genes, encoded proteins, recombinant production methods; for diagnostics and therapeutics.
Zeneca WO 00/12698
Deltex Notch signal protein
Human Deltex-like gene, encoded Deltex Notch signaling protein; for regulating tissue physiology.