I. COMMENCED TRADING IN MARCH

Company
(Symbol)#

Date
Filed

Date
Comm.

Shares/
Units (M)

Price

Shares
Out
(M)@

Lead, Other
Underwriters

Gross
(US$M)

Post-
Offering
Market
Cap (M)%

INITIAL OFFERINGS

Enanta Pharmaceuticals Inc. (Watertown, Mass.; ENTA)1

11/6/12

3/21/13

4.6S

$14

17.44

J.P. Morgan
Credit Suisse (co-lead)
Leerink Swann
JMP Securities

$64.4

$244.16

Tetraphase Pharmaceuticals Inc. (Watertown, Mass.; TTPH)2

2/11/13

3/20/13

10.7S

$7

19.9

Barclays
BMO Capital Markets (co-lead)
Stifel
JMP Securities
Needham & Co.

$75

$139.3


Total: $139.4M

Number of IPOs in March: 2

Average value of March IPOs: $69.7M

Number of IPOs in 2013: 4

Total raised in IPOs in 2013: $247.6M

Average value of IPOs in 2013: $61.9M

Company
(Symbol)#

Date
Filed

Date
Comm.

Shares/
Units (M)

Price

Shares
Out
(M)@

Lead, Other
Underwriters

Gross
(US$M)

Post-
Offering
Market
Cap (M)%

FOLLOW-ON OFFERINGS

Achillion Pharmaceuticals Inc. (New Haven, Conn.; ACHN)3

11/21/12

3/1/13

16.9S

$8.40

96.6

Citigroup
Leerink Swann (co-lead)
JMP Securities LLC
Piper Jaffray & Co.
Wells Fargo Securities

$141.96

$811.4

Cerus Corp. (Concord, Calif.; CERS)4

1/10/12

3/14/13

8.3S

$4.20

64.59

Cowen & Co.
Baird
Wedbush PacGrow Life
Lazard Capital Markets

$35

$271.3

Cynapsus Therapeutics Inc. (Toronto; TSX-V:CTH)

3/1/13

3/18/13

15.9U

C46

N/A

M Partners Inc.

C$7.3 ($7.14)

N/A

Hyperion Therapeutics Inc. (South San Francisco; HPTX)5

3/8/13

3/8/13

3.23S

$20.75

19.95

Leerink Swann
Cowen & Co. (co-lead)
Needham & Co.
JMP Securities

$67

$413.96

Imprimis Pharmaceuticals Inc. (Solana Beach, Calif.; IMMY)6

2/11/13

3/14/13

0.276S

$5.25

8.876

MDB Capital Group
Aegis Capital (co-lead)

$1.45 (overallotment option)

$46.6

Inovio Pharmaceuticals Inc. (Blue Bell, Pa.; NYSE:INO)

9/2/11

3/7/13

27.38S and W for 13.69S

$0.55

179.9

Cowen & Co.
Brean Capital
Maxim Group LLC

$15.06

$98.945

Medgenics Inc. (San Francisco; MDGN)7

10/26/12

3/26/13

6.07S and Series 2013-A W for 3.22S

$5.25

18.37

Maxim Group LLC
National Securities Corp.
MLV & Co.

$31.87

$96.4

Oculus Innovative Sciences Inc. (Petaluma, Calif.; OCLS)8

5/3/11

3/7/13

8.625S

$0.40

46.09

Aegis Capital Corp.
Dawson James Sec.

$3.45

$18.436

Pharmacyclics Inc. (Sunnyvale, Calif.; PCYC)9

3/7/13

3/8/13

2.2S

$94.20

72.4

J.P. Morgan

$207.24

$6.82B

Stem Cell Therapeutics Corp. (Toronto; TSX-V:SSS)

3/7/13

3/7/13

1.3U

C$0.25

N/A

Euro Pacific Canada Inc.
Blook Burton & Co.

C$3.1 ($3)

N/A

Tesaro Inc. (Waltham, Mass.; TSRO)10

2/27/13

3/1/13

5.4S

$18

32.57

Citigroup
Morgan Stanley (co-lead)
Leerink Swann
Deutsche Bank Sec.
BMO Capital Markets
Baird

$22.2 ($97.2 total raised)

$586.26


Total: $608.92M

Number of follow-on offerings in March: 10

Average value of March follow-ons: $60.89M

Number of follow-on offerings in 2013: 32

Total raised in follow-ons in 2013: $3,001.2M

Average value of follow-ons in 2013: $93.79M


Notes:

# Unless otherwise indicated, shares are traded on the Nasdaq exchange. NYSE = New York Stock Exchange. TSX-V = Toronto Stock Venture Exchange. @ This column reflects the shares outstanding following the offering, when disclosed. % Market capitalization is calculated based on the offering price. Currency conversions are based on exchange rates at the time of the deal.

1 Enanta's overallotment option: 600,000 shares.

2 Tetraphase's overallotment option: 1.6M shares.

3 Includes Achillion's overallotment option: 1.9M shares.

4 Cerus' overallotment option: 1.25M shares.

5 Includes Hyperion's overallotment option: 431,250 shares.

6 Imprimis' underwriters exercised the overallotment option, bringing the total shares offered to 2.1M shares and the total amount raised to $ 11.11M.

7 Medgenics completed the overallotment option of its February public offering., bringing the total to $31.87M.

8 Includes Oculus' overallotment option: 1.125M shares.

9 Pharmacyclics' overallotment option: 330,000 shares.

10 Includes Tesaro's overallotment option: 708,000 shares.

II. FILED AND PENDING

Company
(Symbol)#*

Date Filed

Shares/Units (M)

Price

Shares Out

Lead, Other Underwriters

Gross (US$M)

INITIAL OFFERINGS

Alcobra Ltd. (Tel Aviv, Israel; ADHD)1

3/19/13

1.365S

$10-$12

9.25

Aegis Capital Corp.

$15

Ambit Biosciences Inc. (San Diego; AMBI)

2/20/13

N/A

N/A

N/A

Citigroup
Leerink Swann (co-lead)
BMO Capital Markets
Baird

$86.25

Audeo Oncology Inc. (San Francisco; AURX)2

7/6/12

3.25S

$14-$16

10.8

Leerink Swann
Oppenheimer & Co. (co-lead)

$49

Chimerix Inc. (Research Triangle Park, N.C.; CMRX)3

3/8/13

6.1S

$13-$15

23.19

Morgan Stanley
Cowen & Co. (co-lead)
William Blair
Lazard Capital Markets

$85.4

Globeimmune Inc. (Louisville, Colo.; GBIM)

7/2/12

5S

$11-$13

17.23

Wells Fargo Securities
Piper Jaffray (co-lead)
JMP Securities, Needham & Co. MLV & Co.

$60

GW Pharma plc (Porton Down, UK; GWPH)

3/19/13

ADSs

N/A

N/A

Lazard Capital Markets
Cowen & Co. (co-lead)
Canaccord Genuity
Roth Capital Partners

$50

Omthera Pharmaceuticals Inc. (Princeton, N.J.; OMTH)4

3/8/13

5.775S

$12-$14

21.12

BofA Merrill Lynch
Barclays (co-lead)
Leerink Swann (co-lead)
Stifel and Piper Jaffray

$75.075

Oncomed Pharmaceuticals Inc. (Redwood City, Calif.; OMED)

5/11/12

N/A

N/A

N/A

Jefferies
Leerink Swann (co-lead)
Piper Jaffray
BMO Capital Markets

$115

Paratek Pharmaceuticals Inc. (Boston; PRTK)

9/27/12

N/A

N/A

N/A

UBS Investment Bank
Leerink Swann (co-lead)
Lazard Capital

$92

Sophiris Bio Inc. (San Diego; SPHS)

2/15/13

N/A

N/A

N/A

Citigroup
Leerink Swann (co-lead)
Stifel
Lazard Capital Markets

$74.75


Notes: # Unless otherwise indicated, shares are traded on the Nasdaq exchange.

General shelf registration statements are not included until action is taken on the filing. * Stock symbols for companies seeking to complete IPOs are proposed. @ This column reflects the shares outstanding following the offering, when disclosed.

N/A = Not available, applicable or reported.

The value of all offerings is based on either the midpoint of the price range listed in the company's SEC filing or the most recent closing stock price before the offering was announced. In some cases, the company has not disclosed the number of shares to be offered or a price range. Then, the value is the maximum aggregate offering price listed in the SEC filing.

1 Alcobra's overallotment option: 204,750.

2 Audeo's overallotment option: 487,500-shares.

3 Chimerix's overallotment option: 915,000 shares.

4 Omthera's overallotment option: 866,250 shares.