“Clearly there have been a lot of questions from physicians on what to do with the results of CLOSURE I. I think the study that we'll be doing is a bit different.“

– John Rhodes, MD, a principal investigator for Gore's REDUCE trial, on the disappointing results of NMT Medical's CLOSURE I trial that sought to establish a link between PFOs and stroke,and how Gore's trial for the indication will be different,“ pp. 1 , 6.