• Arthrosurface (Franklin, Massachusetts) said it has received FDA approval to begin a pivotal study for its line of focal knee resurfacing implants. With the HemiCAP knee implant, the company is targeting a subgroup of knee patients, typically between the ages of 40 and 60, who have focal condylar defects and are likely to undergo knee replacement surgery in the future. HemiCAP resurfacing is intended to bridge the gap between biologic procedures and conventional joint replacement. Arthrosurface's minimally invasive resurfacing system allows for preservation of healthy tissue and joint structures by limiting treatment to localized defects using a shallow inlay implant that is matched to the patient's own joint surface anatomy. Arthrosurface makes joint resurfacing systems.

The National Institutes of Health (NIH) has informed CHF Solutions (Brooklyn Park, Minnesota) that the CARRESS-HF trial has begun enrolling patients. Sponsored by NIH's National Heart, Lung, and Blood Institute and chosen out of 16 national submissions for studies in heart failure, this study will compare CHF Solutions' Aquapheresis therapy with standard medical drug therapy in patients hospitalized with acute decompensated heart failure and cardiorenal syndrome. Fluid overload can be caused by problems with the heart, kidneys, liver and lungs, and is frequently experienced after surgical operations, trauma, and burns. The leading cause of fluid overload is congestive heart failure (CHF), sometimes referred as just heart failure. Heart failure is a condition that affects about 5 million Americans and is responsible for over 3.1 million primary and secondary hospitalizations annually. CHF Solutions' Aquapheresis therapy is a mechanical method to safely and effectively remove the excess salt and water in patients with fluid overload. CHF makes cardiac care devices.

• Imaging Sciences International (Hatfield, Pennsylvania), a maker of Cone Beam 3-D dental imaging, said it is the first Cone Beam scanner (i-CAT) to be certified by OraMetrix, a provider of technology-based orthodontic care solutions, for integration with the latest advancements in SureSmile technology, which transforms Cone Beam scans of the mouth and teeth into 3-D computer models for orthodontic treatment planning and treatment. The SureSmile system is a doctor-driven digital therapeutic solution for the practice of orthodontics that replaces conventional manually-managed treatment. Orthodontists now can take an i-CAT scan of the patient's mouth, face, and jaw, and use this data in the SureSmile system for unprecedented control of treatment through virtual diagnostic simulations, instant quality grading tools, prescriptive planning capabilities and robotic arch-wire customization. The i-CAT makes anatomically accurate 3-D views of all oral and maxillofacial structures at a lower cost with less radiation to patients than traditional CT scans. Imaging Sciences International makes computer-controlled dental and maxillofacial radiography products.