BrainLAB (Westchester, Illinois) reported receiving FDA clearance for its Monte Carlo Dose Calculation Algorithm, which already is being used at several clinical cooperation sites worldwide. The BrainLAB Monte Carlo Dose Calculation software is an algorithm for therapeutic photon beams supporting nearly all linear accelerator and multi-leaf collimator (MLC) types. Monte Carlo is now available as an option on the iPlan RT Dose treatment planning software. Dose calculations can be completed within seconds for conformal beam and dynamic arc treatments and within a few minutes for complex IMRT cases. This dose-calculation engine provides an advanced level of integration, which means its use is not limited to a single machine, multi-leaf collimator, energy or treatment modality and can be seamlessly integrated to drive treatment with Varian, Siemens and Elekta MLCs and linear accelerators. BrainLAB makes software-driven systems for targeted, less-invasive medical treatments.