Cardiac Science (Irvine, California), a manufacturer of automated external defibrillators (AEDs) and provider of comprehensive AED/CPR training and AED program management services, said it has entered into a national training agreement with the American Heart Association (AHA; Dallas, Texas). The agreement establishes Cardiac Science as an AHA-approved National Training Center and authorizes the company to conduct and administer AHA-accredited training courses in basic life support and emergency cardiovascular care and provide the association's educational materials for its customers throughout the nation.

Coronado Industries (Fountain Hills, California), a maker of pneumatic devices for the treatment of glaucoma, said its marketing team has signed an exclusive sales and distribution agreement covering the Portuguese market. The agreement was executed with Izasa SA (Madrid, Spain). Distribution of the products will be through Izasa's wholly owned subsidiary, Izasa Portugal (Lisbon and Porto, Portugal).

CryoLife (Kennesaw, Georgia), a human tissue processing and biosurgical device company, said it has licensed a patented technology from Clearant (Los Angeles, California) designed to inactivate microorganisms, including pathogens, from tissue obtained from human donors. A pathogen is any agent that causes disease in humans, including bacteria, viruses and fungi. CryoLife plans to further develop and employ the technology in processing human orthopedic tissue primarily used in the repair of sports injuries. The technology is based on gamma irradiation and is designed to substantially reduce microbial contamination and other pathogens while maintaining tissue integrity.

Cytyc (Boxborough, Massachusetts) and Abbott Laboratories (Abbott Park, Illinois) unveiled a collaboration and co-promotion agreement for the development and marketing of the ThinPrep UroCyte Slide Preparation System. Initial efforts will focus on modifying Cytyc's ThinPrep sample preparation technology to be used in conjunction with UroVysion, a DNA probe-based test for detection of bladder cancer recurrence. Both companies will promote this new system following completion and regulatory clearance of the co-developed product. The UroVysion Bladder Cancer Recurrence Kit is the first and only FDA-cleared molecular urine cytology test that uses DNA probes to identify chromosomal abnormalities in patients previously diagnosed with bladder cancer.

Lifeline (Reno, Nevada) has signed an exclusive North American distribution agreement with Inion (Oklahoma City, Oklahoma) to distribute its Hexalon bioabsorbable ACL/PLC Screws and accessories to the orthopedic market. Lifeline said that with the design and strength advantages the Hexalon offers, its distribution network should be able to make an impact in what is estimated as a $72 million market. A joint product launch will take place at the American Academy of Orthopaedic Surgeons (Rosemont, Illinois) meeting in San Francisco, California, in March.

Royal Philips Electronics (Amsterdam, the Netherlands) signed a seven-year agreement to provide Baptist Health South Florida with radiology and cardiology picture archiving and communication systems (PACS), allowing physicians to access patient records across all Baptist Health facilities. Philips said the agreement represents one of the largest PACS multi-hospital, single-database solutions in the world. Baptist Health South Florida includes eight hospitals and one outpatient service. The PACS solution will be implemented in a phased approach that started late last year and is expected to be complete across the enterprise in 2005. Philips Medical Systems PACS products are designed and developed in partnership with Sectra Imtec AB, Sweden.

R2 Technology (Sunnyvale, California) a developer of computer-aided detection (CAD) technology, and the University of Chicago Medical Center (Chicago, Illinois), a recognized pioneer in CAD development, have entered into an exclusive license agreement to accelerate development of a mammographic CAD workstation reference library for the early detection of breast cancer. The investigational CAD reference library contains a database of both malignant and benign lesions, which radiologists can access for clinical comparison and relevancy. R2's ImageChecker system was the first mammography CAD system approved by the FDA and the first to be approved for use with digital mammography.

Vital Images (Plymouth, Minnesota), a medical imaging software company, has renewed its U.S. and international marketing and distribution agreement with Toshiba Medical Systems (Tochigi, Japan). As under the previous agreement, Toshiba will offer Vital Images' Vitrea 2 software through its subsidiaries and distributors in more than 50 nations in North and South America, Europe, the Middle East, Africa, Australia and Asia, except Japan. Since 2000, Toshiba has been offering Vitrea software as the 3-D medical imaging product of choice to customers purchasing Toshiba's Aquilion and AsteonTM CT scanners. The new agreement is effective through the end of 2004.