Aegis Analytical Corp., of Lafayette, Colo., received notices of allowance for patents covering its Discoverant data access and user interface technologies.

BioSeek Inc., of Burlingame, Calif., was awarded U.S. Patent No. 6,656,695 titled "BioMAP Characterization of Biologically Active Agents," covering methods and applications of its BioMAP technology for screening compounds as potential therapeutics for inflammatory diseases.

Chiral Quest Inc., of State College, Pa., said The Penn State Research Foundation was issued U.S. Patent No. 6,653,485 covering the compositions of matter for a variety of ortho-substituted chiral biaryl phosphine ligands. The company exclusively licenses the patent.

Lexicon Genetics Inc., of The Woodlands, Texas, received U.S. Patent No. 6,653,113 titled "High Efficiency Gene Targeting in Mouse Embryonic Stem Cells," covering methods of producing genetically engineered knockout mice by gene targeting.

MorphoSys AG, of Munich, Germany, was granted U.S. Patent No. 6,653,068 titled "Generation of Specific Binding Partners to (Poly)Peptides Encoded by Genomic DNA Fragments or ESTs," covering methods for the production of expressed sequence tags as fusion proteins and subsequent generation of HuCAL antibodies against those proteins.

Nanobac Pharmaceuticals Inc., of Tampa, Fla., received a notice of allowance for a third patent associated with the detection, treatment and eradication of nanobacterial infection and contamination, covering methods of disinfecting articles and patients infected with nanobacteria.

Nanogen Inc., of San Diego, was issued U.S. Patent No. 6,652,808 titled "Methods for the Electronic Assembly and Fabrication of Devices," the parent of a series of pending patent applications that the company said would broaden its position in the nanotechnology and nanomanufacturing areas.