3-Dimensional Pharmaceuticals Inc., of Exton, Pa., was issued U.S. Patent No. 6,245,763 titled ¿Heteroaryl Aminoguanidines and Alkoxyguanidines and their Use as Protease Inhibitors.¿ The patent encompasses the use of these chemical compounds as inhibitors of trypsin-like serine protease enzymes. They have been shown to inhibit the enzyme thrombin, which plays a role in blood clotting.

Aastrom Biosciences Inc., of Ann Arbor, Mich., was awarded U.S. Patent No. 6,238,908 titled ¿Apparatus and Method for Maintaining and Growing Biological Cells.¿ This patent covers an integrated system of instrumentation and the related methods of receiving, maintaining and growing human cells ex vivo within a portable cassette, without exposing the cells to the external environment.

American Biogenetic Sciences Inc., of Copiague, N.Y., was awarded U.S. Patent No. 6,268,396 titled ¿Use of Valproic Acid Analog for the Treatment and Prevention of Migraine and Affective Illness.¿

Curis Inc., of Cambridge, Mass., was issued U.S. Patent No. 6,261,786 in the field of small molecules titled ¿Screening Assays for Hedgehog Agonists and Antagonists.¿ The patent covers an assay for identifying compounds that inhibit or potentiate binding of a hedgehog polypeptide to a naturally occurring patched receptor.

Large Scale Biology Corp., of Vacaville, Calif., was awarded U.S. Patent No. 6,284,492 covering methods for recombinant animal viral nucleic acids, allowing LSBC to extend its genomic and proteomic studies to animal cells.

Molecular Staging Inc., of New Haven, Conn., was awarded two patents for Rolling Circle Amplification Technology, including U.S. Patent No. 6,287,824 for ¿Molecular Cloning Using Rolling Circle Amplification.¿ This application of Rolling Circle Amplification Technology enables scientists to clone DNA without using biological host organisms such as bacteria, viruses or yeast cells. The company also was awarded U.S. Patent No. 6,287,825 titled ¿Methods for Reducing the Complexity of DNA Sequences.¿ This patent adds to the existing patent portfolio on allele frequency distortion.