May 2 (EPO), April 26 (WO); May 2 (GB)

Abbott Labs WO 01/29264

Tumor cell detection

Abbott Park, Ill.

Nucleic acid primers and probes for amplification to detect CK19 target tumor-related gene sequences.

Advanced Cell Technol. WO 01/29206

Producing progenitor cells

Worcester, Mass.

Methods for producing differentiated progenitor cells and lineage-defective embryonic stem cells.

Affymetrix WO 01/29259

Allele identification

Santa Clara, Calif.

Genotyping using primer extension amplification with sequence-coded identity tags; for finding allele frequency.

Affymetrix WO 01/29267

Identifying maintenance genes

Santa Clara, Calif.

Methods for identifying maintenance genes by comparing expression levels in several samples.

Agilent Technol. GB 2 355 716

Array fabrication

Santa Clara, Calif.

Modified inkjet printing system used to fabricate polynucleotide arrays.

Agouron Pharma EP 1 096 014

Checkpoint protein kinase

La Jolla, Calif.

Catalytic domain of the human cell cycle checkpoint protein kinase Chk1, encoding gene; for finding inhibitors.

Akzo Nobel WO 01/29081

Autoimmunity immunotherapy

Arnhem, Netherlands

Modified peptides and peptidomimetics for use in immunotherapy of autoimmune diseases.

Amersham Pharmacia Biotech GB 2 355 717

DNA isolation

Amersham, UK

Isolation of DNA or cell nuclei in micro-channels in an apparatus with a rotatable disk.

Arkansas, Univ. of WO 01/29056

Breast cancer therapeutics

Little Rock, Ark.

TADG-15 protein, encoding gene sequences; for finding inhibitors and developing breast cancer therapeutics.

Artemis Pharma WO 01/29208

Inactivating genes

Cologne, Germany

Gene trapping construct that causes conditional mutations in genes; for mutational inactivation of cellular genes.

Avatar Medical WO 01/29247

Stabilized proteins

Newark, N.J.

Methods for mutagenizing and controlled cross-linking of proteins; for stabilization.

Aventis Pharma EP 1 096 012

ABC1 gene

Antony, France

Human ABC1 gene sequences, encoded protein; for developing cholesterol metabolism diagnostics and therapeutics.

Aventis Pharma WO 01/29234

Controlling protein synthesis

Antony, France

Insertion of untranslated regions into an mRNA sequence; for self-cleavage to control protein synthesis.

BASF WO 01/29227

Lipid body lipoxygenase

Ludwigshafen, Germany

_-barrel of lipid body lipoxygenase, encoding gene; for developing therapeutics for lipid metabolism control.

Biomerieux WO 01/28683 & 28685

Amplification test strips

Hazelwood, Mo.

Disposable test strips for devices to perform nucleic acid amplification reactions.

Canji WO 01/28569

Gene delivery vehicles

San Diego

Gene delivery vehicles having the targeting moiety attached by transition metal ions; for ease of moiety attachment.

Case Western Res. Univ. WO 01/29269

IBD gene expression profiles

Cleveland, Ohio

Gene expression profiling of patients with inflammatory bowel disease.

Colorado, Univ. of WO 01/29062

Modulating cell phenotype

Boulder, Colo.

Modulating cell phenotype using genes encoding proteins with CREB biological activity; for treating diabetes and obesity.

Compugen WO 01/29215

N-CAM homologs

Tel Aviv, Israel

Neural cell adhesion molecule homologs, splice variants; for developing diagnostics and therapeutics.

CuraGen WO 01/29071

Obesity-associated genes

New Haven, Conn.

Genes associated with obesity, differential expression assays for diagnosis and modulator screens.

CuraGen WO 01/29217

Human proteins

New Haven, Conn.

Human proteins, encoding gene sequences, antibodies, variants, mutants, fragments; for developing therapeutics.

CuraGen WO 01/29268

Interacting gene products

New Haven, Conn.

Methods for identifying interacting gene products, such as members of protein-protein complexes.

Dalhousie Univ. WO 01/29243

Transferring spliced proteins

Halifax, N.S.

Methods and vectors for producing and transferring trans-spliced peptides that form a complete protein.

Digital Gene Technol. WO 01/29179

Neuromodulator regulated genes

La Jolla, Calif.

Genes and proteins related to neural disease; for regulation by neuromodulators.

Du Pont WO 01/29261

Gene expression profiling

Wilmington, Del.

Methods for high-density microarray-mediated comprehensive gene expression profiling.

Emory Univ. WO 01/29235

Silenced methylated gene

Atlanta

TMS1 gene that is transcriptionally silenced by methylation; for diagnostics and therapeutics.

Enchira Biotech WO 01/29211 & 29212

Directed gene evolution

The Woodlands, Texas

Directed evolution of whole genomes and large DNA sequences by random chimeragenesis on transient templates.

European Molec. Biol. Lab WO 01/29231

Genetic switches

Heidelberg, Germany

Genetic switches that use a Cre recombinase; for making transgenics.

Genaissance Pharma WO 01/28995 & 29176

Cholinergic receptor SNPs

New Haven, Conn.

Polymorphisms in the cholinergic receptor muscarinic 3 and 5 genes; for population genotyping.

Genaissance Pharma WO 01/29263

Serotonin receptor SNPs

New Haven, Conn.

Polymorphisms in the serotonin receptor gene; for population genotyping.

Genena WO 01/29210

Connecting gene sequences

Moshav Herut, Israel

Methods for establishing connections between the regulatory region of genes and various structural genes.

Genentech WO 01/29070

T cell differentiation

S. San Francisco

Type 1 cytokine receptor, encoding gene sequences, modulators; for modifying T cell differentiation.

Genset WO 01/29257

Genetic cluster analysis

Paris

Methods for genetic cluster analysis using DNA fingerprinting in patient populations.

Ghent Univ. WO 01/29251

Neurofibromatosis 1 gene mutations

Ghent, Belgium

Enhanced mutation analysis of the neurofibromatosis 1 gene; for diagnostic and therapeutic development.

Ghent Univ. WO 01/29254

Blepharophimosis syndrome gene

Ghent, Belgium

Identification of a gene disrupted by a balanced chromosomal translocation in blepharophimosis syndrome.

Glaxo WO 01/29255

Cephalic pain diagnosis

Greenford, UK

Genotyping DNA sequences in the insulin receptor gene region; for diagnosing susceptibility to cephalic pain.

Heska WO 01/29078

Mite protein production

Ft. Collins, Colo.

Production of mite group 1 proteins in methylotrophic yeast or E. coli; for vaccines.

Hisamitsu Pharma WO 01/29244

Nucleic acid delivery

Saga, Japan

Nucleic acid transporter made from a protein containing diaminobutyric acid; for high level transgene expression.

Histatek WO 01/29069

Inflammatory agent

San Francisco

N-formyl peptide receptor complex with a G-protein kinase signal pathway modification agent; for inflammation.

Human Genome Sciences WO 01/29063

Death domain receptor

Rockville, Md.

Death domain-containing receptors, encoding gene sequences, antibodies, recombinant production methods.

Human Genome Sciences WO 01/29564

Protein tyrosine kinase receptor

Rockville, Md.

Protein tyrosine kinase receptor, encoding gene, antibodies production methods; for diagnostics and therapeutics.

Icos EP 1 096 016

Platelet-activating factor

Bothell, Wash.

Platelet-activating factor acetylhydrolase, encoding gene sequences; for developing inflammation therapeutics.

Iowa, Univ. of WO 01/29216

Sarcospan-deficient mice

Iowa City, Iowa

Sarcospan-deficient mice; for modeling clinical disorders associated with adipose tissue deposition.

Isis Pharma WO 01/29057

bcl-6 antisense

Carlsbad, Calif.

Antisense modulation of bcl-6 expression; for treating diseases associated with bcl-6 expression.

Isis Pharma WO 01/29175

fra-1 antisense

Carlsbad, Calif.

Antisense modulation of fra-1 expression; for treating diseases associated with fra-1 expression.

Japan Sci. & Technol. WO 01/28321

Diabetes onset transgenics

Saitama, Japan

Transgenics having the imprinting gene Meg1/Grb10; for studying diabetes onset.

Johns Hopkins Univ. WO 01/29233

Chimeric immunogenic agents

Baltimore

Chimeric immunogenic compositions having heat shock protein and cytokine domains, encoding gene sequences.

Juvantia Pharma WO 01/29082

Variant adrenoreceptor

Turku, Finland

Variant adrenoreceptor, encoding gene, transgenics; for developing coronary vascular restriction therapeutics.

Kyowa Hakko Kogyo WO 01/29246

Antibody production

Tokyo

Process for producing antibodies in rat cells cultured in serum-free medium.

Leadd WO 01/29226

Apoptosis-inducing protein

Leiden, Netherlands

Apoptosis-inducing protein that affects tumor cells but not normal cells; for cancer developing therapeutics.

Lexicon Genetics WO 01/29084

Human proteins

The Woodlands, Texas

Human proteins, encoding gene sequences; for developing diagnostics and therapeutics.

Lexicon Genetics WO 01/29219

CUB domain protein

The Woodlands, Texas

Human CUB domain-containing protein, encoding gene sequences; for diagnostics and therapeutics.

Ludwig Inst. Cancer Res. WO 01/29220

MAGE antigenic peptides

New York

Antigenic peptides derived from MAGE-A12 polypeptides that are presented by HLA molecules; for cancer therapy.

Massachusetts, Univ. of WO 01/29058

RNA interference genes

Boston, Mass.

Genes involved in the double-stranded RNA interference pathway; for developing modulators.

Max Planck Inst. WO 01/29068

Potassium ion channel

Berlin

Human potassium ion channel, encoding gene, antisense; for developing cancer and neural disease therapeutics.

McGill Univ. WO 01/29266

Spastin gene mutations

Montreal

Isolated spastin genes and encoded proteins, fragments, altered forms; for neurodegenerative disease diagnosis.

MRC (Med. Res. Counc.) WO 01/29236

Membrane protein expression

London

Expression system for membrane proteins; for isolation and purification.

Millennium Pharma WO 01/29088

Therapeutic proteins

Cambridge, Mass.

Therapeutic and diagnostic proteins, encoding gene sequences, transgenics, antibodies.

Millennium Pharma WO 01/29199

Cyclic nucleotide phosphodiesterase

Cambridge, Mass.

Human cyclic nucleotide phosphodiesterase, encoding gene; for diagnostics, therapeutics, and finding modulators.

Molecular Light Technol. Res. GB 2 355 791

RNA detection

Cardiff, UK

Detecting RNAs using oligonucleotide probes labelled with chemiluminescent molecules; for studying transcription.

Novo Nordisk Biotech WO 01/29222

Phospholipase A-like protein

Davis, Calif.

Phospholipase A-like protein, encoding gene sequences, production methods; for developing therapeutics.

Ohio State Univ. WO 01/29059

Group II intron insertion activity

Columbus, Ohio

Methods for analyzing the insertional capabilities of modified group II introns.

Orchid Biosciences WO 01/29262

Genotyping reagents

Princeton, N.J.

Oligonucleotides for determining the presence and identity of single nucleotide polymorphisms.

Osaka Univ. GB 2 355 718

Modified recombinase gene

Osaka, Japan

Modified Cre recombinase gene having codons used frequently in mammalian cells; for gene manipulation.

Panorama Res. WO 01/29225

Optimizing protein expression

Mountain View, Calif.

Optimizing the expression of heterologous proteins by selecting autonomously folding domains from cDNA libraries.

Peptide Solutions WO 01/29177

HIV vaccines

Columbia, Md.

Mutated forms of HIV-1 subtype D peptides having altered hydrophilic residues; for vaccines.

Pittsburgh, Univ. of WO 01/29218

Nuclear matrix proteins

Pittsburgh, Penn.

Nuclear matrix proteins from prostate tissue, encoding gene sequences; for developing diagnostics and therapeutics.

Prince Henry's Inst. Med. Res. WO 01/29079

Inhibin subunit fragments

Clayton, Australia

Immuno-interactive fragments of the aC subunit of inhibin; for therapeutic development.

Rigel Pharma WO 01/29072

Cell cycle-associated proteins

S. San Francisco

Cell cycle-associated proteins, encoding genes, antibodies, production methods; for affecting the cell cycle.

Scios WO 01/29232

Cloning proteolytic enzymes

Sunnyvale, Calif.

Functional cloning of genes encoding proteins and enzymes involved in proteolytic cleavage using caspase cassettes.

Shanghai Bio Road Gene Develop. WO 01/29075

G-protein activating protein

Shanghai, China

G-protein activating protein, encoding gene sequences, production methods; for therapeutic development.

Shanghai Bio Road Gene Develop. WO 01/29076

Human p24 protein

Shanghai, China

Human p24 protein, encoding gene sequences, production methods; for therapeutic development.

Shanghai Bio Road Gene Develop. WO 01/29077

Human _-microglobin regulatory factor

Shanghai, China

Human _-microglobin regulatory factor, encoding gene sequences, production methods; for therapeutic development.

Shanghai Bio Road Gene Develop. WO 01/29080

High mobility group protein

Shanghai, China

Human high mobility group protein 13, encoding gene sequences, production methods; for therapeutic development.

Shanghai Bio Road Gene Develop. WO 01/29228

Casein kinase

Shanghai, China

Human casein kinase, encoding gene sequences, production methods; for therapeutic development.

Shanghai Bio Road Gene Develop. WO 01/29229

Retinoblastoma binding protein

Shanghai, China

Human retinoblastoma binding protein, encoding gene sequences, production methods; for therapeutic development.

SmithKline Beecham WO 01/29089

Rat 7-transmembrane receptor

Philadelphia

Rat 7-transmembrane receptor, encoding gene sequences, recombinant production methods; for modulator screens.

SmithKline Beecham WO 01/29178

EPO primary response gene

Philadelphia

EPO primary response gene, encoded protein, recombinant production methods; for diagnostics and therapeutics.

SmithKline Beecham WO 01/29214

Colon tumor antigens

Rixensart, Belgium

Colon tumor-associated antigens, encoding gene sequences; for cancer diagnostics and therapeutics.

Speicher, M. WO 01/29252

Repeat-depleted DNA

Riemerling, Germany

Generating repeat-depleted DNA using amplification methods; for DNA array hybridization.

Speicher, M. WO 01/29253

Visualizing heterochromatin

Riemerling, Germany

Simultaneous visualization of eu- and heterochromatin; for diagnostics.

Taiho Pharma WO 01/29207

Uracil antibodies

Tokyo

Monoclonal antibodies to uracil; for immunological measurement of uracil and thymidine in samples.

Texas Biotech WO 01/29083

Adhesion proteins

Houston

Human and mouse adhesion proteins, encoding gene sequences; for developing therapeutics.

Transgene EP 1 096 018

Complementation cells

Strasbourg, France

Complementation cells containing an inducer or a repressor [in French].

Ventana Medical Systems WO 01/29265

Single gene copy detection

Tucson, Ariz.

Methods for detecting single gene copies in situ using brightfield microscopy and a chromogen molecule.

Welfide EP 1 096 017

Increasing protein production

Osaka, Japan

Increasing recombinant protein production from cell cultures using cobalt and molybdenum in the culture medium.

Wellcome Trust WO 01/29213

SIT4-associated proteins

London

Human SIT4-associated proteins, encoding genes; for diagnostics and therapeutics.

Yale Univ. WO 01/29249

DNA cloning constructs

New Haven, Conn.

Conjoined polynucleotide catalysts having at least two domains; for DNA cloning.

ZymoGenetics WO 01/29221

Signal sequence fusion proteins

Seattle

Fusion proteins having a signal sequence, encoding gene sequences, modulators; for developing therapeutics.

ZymoGenetics WO 01/29223

Membrane protein

Seattle

Type 1 membrane protein, encoding gene sequences, antibodies, affinity tag fusions; for cancer diagnosis.

ZymoGenetics WO 01/29224

Granulocyte peptide homolog

Seattle

Granulocyte peptide homolog, encoding gene sequences, fusions, chimeric affinity tags; for therapeutics.

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